Holmes & Watson is a comedic take on the famed literary characters Sherlock Holmes and Dr. John Watson as they use their brilliant minds to stop rival James Moriarty from assassinating the queen. Devo's member Mark Mothersbaugh composed the music to the movie, which stars Will Ferrell and John C. Reilly. As we follow the plot of the famed detective duo as they set out to find the culprit behind a threat at Buckingham Palace, the music follows a path of entertaining orchestral sounds.